Journal of Molecular Catalysis A-Chemical, Vol.260, No.1-2, 105-108, 2006
A new route for isoquinolines catalyzed by palladium
3-Bromopyridine-4-carbaldehyde is tethered with suitably electron withdrawing group substituted alkenes via Heck coupling followed by aldol reaction in dioxane at 150 degrees C under a catalytic system of Pd(OAc)(2)/PPh3/NaOAc to afford the corresponding isoquinolines in good yields. (c) 2006 Elsevier B.V. All rights reserved.
Keywords:alkenes;3-bromopyridine-4-carbaldehyde;heck and aldol reactions;isoquinolines;palladium catalyst