The synthesis of biheteroaryl derivatives by palladium-catalysed Suzuki cross-coupling reaction of heteroaryl bromides with heteroaryl-boronic acids is a challenging reaction due to the electronic and/or poisoning properties of these heteroaryl compounds. Through the use of [PdCl(C3H5)](2)/cis,cis,cis-1,2,3,4-tetrakis(diphenylphosphinomethyl)cyc lopentane as a catalyst, a range of heteroaryl bromides undergoes Suzuki reaction with heteroarylboronic acids such as thiophene-, furan-or pyridineboronic acid derivatives in good yields. This catalyst can be used at low loadings with several substrates. In general bromopyridines were found to be more reactive than bromothiophenes or bromofuranes. (c) 2007 Elsevier B.V. All rights reserved.