The adsorption isotherms of hydrogen and deuterium in a helium carrier gas at 77 K were obtained, using the molecular sieve 5A as adsorbents in a fixed column. The binary adsorption isotherms were extended from the single ones. The kinetic model was built for simulation of the concentration distribution for single and binary in inert helium carrier gas, and compared with the experimental results. Some parameters in the model were considered and examined experimentally. (C) 2003 Elsevier B.V. All rights reserved.