The adsorption behavior of a hydroxypropyl methyl cellulose (HPMC) polymer in aqueous suspensions of alumina, silica, kaolin, and talc powders, two-component combinations, and one three-component combination was determined. Powders were well characterized by chemical analysis, XRD, DRIFT, SEM, particle size, surface area, and density analyses. The zeta-potential of each powder in aqueous suspension was determined over a range of pH to determine particle charging and the isoelectric point for each material. Alumina and silica powders having heavily hydroxylated surfaces were observed not to adsorb the HPMC polymer over a range of pH. The Layer-type minerals talc, which was noticeably hydrophobic, and kaolin, which had differently hydrated basal planes, adsorbed the HPMC polymer but in different amounts per unit of surface area. In the two-component systems, HPMC polymer adsorption for systems of dispersed particles of Like electrical charge (kaolin + silica, talc + silica or alumina, and kaolin + talc) was proportionate to the sum of the fraction x specific surface area x adsorption capacity for each particle type. In systems where particles had an opposite electrical charge (kaolin + alumina, kaolin + talc + alumina), the HPMC polymer adsorption was significantly lower than that calculated for a dispersed system. SEM analysis showed very fine, nonadsorbing alumina particles predominantly on the faces of the adsorbing kaolin particles that apparently masked polymer adsorption. Results suggested a hydrophobic mechanism for the HPMC polymer adsorption and adsorption on only one face of the kaolin particles.