The results of an experimental and numerical modeling study on the inhibition chemistry of CF3CHFCF3 are presented. Burner-stabilized, laminar, premixed, hydrogen-air flat flames with 1.0 and 3.2 mol % inhibitor added were studied as a function of equivalence ratio. The measured concentration profiles of stable species in the postflame gases were modeled with recently developed chemical kinetic mechanisms, augmented with estimated rate and thermochemical data germane to the oxidation of the inhibitor. Agreement between experimental and modeled profiles is adequate for most measured species, thereby partially validating the kinetic data used. Calculated reaction fluxes for 3.7 mol % inhibitor revealed that suppression of H atoms is effected by conversion to HF through reactions with fluorinated species. In contrast, suppression of OH was found to be less effective.