The US private sector has indicated that the National Institute of Standards and Technology (NIST) has a role to play in facilitating the implementation of high throughput experimentation, e.g. using combinatorial methods. The Advanced Technology Program (ATP) is currently funding research projects in high throughput discovery of catalysts, electronic materials, and polymer coatings internally and externally to NIST. The NIST Measurement and Standards Laboratories (MSL) is actively pursuing research in electronic materials and organic polymers. This presentation presents details on these efforts at NIST. (C) 2002 Elsevier Science B.V. All rights reserved.