A new methodology has been proposed that combines structural modelling with genetic programming, and establishes an integrated toolkit for chemical process engineering. The principle is that similarly to the engineering way of thinking the modeling is based on the a priori known structures, while the final evaluation is made in the knowledge of the best detailed simulation experiences. The basic features of the method are the following : The conservational processes are mapped directly onto a descriptive computer program that can be executed by the help of a general purpose simulator automatically. The applied structural modeling technique, separating the invariant and the problem specific actual knowledge, supports the integrated problem solving. The genetic model of the typical time varied process engineering networks is synthesised automatically. There is an evaluation feedback from the synthesized and simulated variants to the genetic elements.