Using a plasma polymerisation process with optical lithography, wet and dry etching techniques we have fabricated an organic micro-fluidic device (OMDF) on silicon/glass substrate. An asymmetric electrode array used in micro-fluidic device (MFD) with small electrode (4 mu m wide) separated from the large electrode (20 mu m wide) by 20 mu m and 6 mu m gaps in both sides respectively. In this study we have found that plasma polymerisation process is not only important for changing the surface chemical and physical properties but also has advantage in bonding of these micro devices at low temperature (similar to 100 degrees C) due to low T-g of polymeric material. The fluidic velocity measurement shows a maximum of about 450 mu m/s in a 150 mu m channel width of organic micro-fluidic devices after plasma surface modification. (c) 2005 Elsevier B.V. All rights reserved.