This paper is the third in a series of papers that explore the challenging problems associated with the design and control of coupled reactor/column systems. In this paper we study a more complex process that consists of a coupled reactor/stripper, two distillation columns and one recycle stream. This study provides a good example for the integration of steady-state design and control design. Effects of various optimization parameters on both design and control were analyzed at the design stage. The how rate of the recycle stream was found to be one of the major optimization parameters that strongly affected the steady-state economics. The effects of impurities in the recycle stream on economics were minor, however, the effect of impurities on controllability was not negligible. A targe number of alternative control structures were explored. One control structure showed multiple closedloop steady-state solutions. An effective control structure was developed and tested for a variety of disturbances.