Communication: Liquid crystalline compounds containing a difluoromethyleneoxy (CF2O) bridge, which increases the polarity, have been synthesized and investigated. The physical properties related to liquid crystal applications (i.e., phase transitions, viscosity, dielectric anisotropy, birefringence) are reported. The compounds show unusually low viscosities in combination with mostly reasonable or good values of the other parameters, making them highly interesting for applications in modern display technologies.