Isotopically enriched (BN)-B-10 nanotubes, shown in the figure, have been produced for the first time. Secondary ion mass spectroscopy analysis confirms a high content of B-10 in the nanotubes. The (BN)-B-10 nanotubes are lightweight, have excellent mechanical properties, a stronger resistance to oxidation than carbon nanotubes, and superior radiation shielding properties, offering a multifunctional material with promising space radiation shielding applications.