The photocatalysis allows the degradation of organic compounds and/or the oxidation/reduction of inorganic compounds (heavy-metal) by the chemical action of the light, in the presence of a catalyst agent. Although the process is natural and fully understood, practical and economic solar detoxification systems are not available yet. With its development, two goals may be achieved: 1) to contribute to a cleaner environment and 2) to save conventional energy, which also pollutes in conventional detoxification plants. In this work, we present the study of the photocatalytic destruction of organic and inorganic compounds by the use of the near UV of the solar spectrum, captured by solar concentrator collectors of the focusing (Hellioman collectors, from PSA, Spain) and non-focusing (CPC, from the USA and Portugal) type. According to recent studies, nonconcentrating collectors can be more interesting for this purpose than concentrating ones, given the higher fraction of diffuse radiation, containing a greater percentage of UV, which can be collected by the previous. However, low concentration (C<2) CPC type collectors can also collect direct and diffuse radiation, being stationary like the flat plate ones and they can be envisaged as an optimized solution for the solar UV collection. An optimization study has been held in order to compare the efficiency and capacity of the pollutants (atrazine, dichloroacetic acid olive mill wastewater, phenol and Cr(VI)) decontamination of the three systems and we have also studied the layout of the collector field, bearing in mind the involved flowrates and time exposure. Titanium dioxide (TiO2) was the chosen catalyst. In this work, the effect of the photocatalysis on the detoxification of aqueous solutions containing organic and/or inorganic compounds as atrazine, dichloroacetic acid, phenol, Cr(VI) and wastewater from a Portuguese olive oil industry, was studied. The results obtained were examined in terms of destruction efficiency and/or oxidation-reduction of the contaminants vs. hydraulic load, concentration and pH effect, and they showed that this process can be used for the detoxification of industrial wastewater.