This paper deals with the environmentally acceptable disposal of the polluting water solutions resulting from the manufacturing of cheese and other similar milk derived products. The proposed treatment, which allows one to recover the most valuable compounds of the milk whey, is based on the integration of a simple purification process with various independent manufacturing processes at different levels. The purification process was obtained by a proper connection of ultrafiltration (UF) treatment with a reverse osmosis (RO) treatment. As a consequence, it is characterized by a significant lower energy consumption in comparison to traditional evaporative processes which allow to produce a much less valuable mixture of both whey proteins and lactose. The process was tested at pilot plant scale by using a previously described multipurpose pilot plant (MPP) equipped with all the automatically controlled units required for this study.