Polymeric vesicles were obtained by a free radical polymerization of aqueous dispersions of the tocopherol-containing nonionic single-chain amphiphile 3 synthesized by the reaction of O-tocopheryloligo(oxyethylene) chloroacetate (2) and 2-(N,N-dimethylamino)ethyl methacrylate. Weight-average molar masses ((M) over bar(w)) of the polymeric vesicles estimated by gel permeation chromatography are in the range of 75000-115000. The phase transition temperature (T-c) of the polymeric vesicles is 77 degrees C, which is higher than that of the monomeric vesicles, 51 degrees C. Transmission electron microscopy photographs show that the polymerization of monomeric vesicles of 3 leads to the formation of mostly polymeric, elliptic vesicles of distinct morphology having short axes of ca. 300-1200 Angstrom and long axes of ca. 600-2400 Angstrom. The polymeric vesicles exhibit an enhanced stability compared with their monomeric counterparts.