Reaction Kinetics and Catalysis Letters, Vol.78, No.1, 193-200, 2003
Kinetics and mechanism of the cleavage of n-methoxyphthalimide (NMPT) in the presence of buffers of Tris (hydroxymethyl)amino-methane (tris) and 1,4-diazabicyclo[2.2.2]octane (DABCO)
The magnitude of hydroxide ion-catalyzed second-order rate constant (k(OH)) for hydrolysis of N-methoxyphthalimide (NMPT) supports the conclusion that the rate law for pH-independent hydrolysis of N-hydroxyphthalimide (NHPTH) is rate = k(OH)[HO-][SH], where SH represents nonionized NHPTH. The second-order rate constants for the reactions of NMPT with DABCO and Tris are (59.7 +/- 6.9) x 10(-3) and (11.9 +/- 2.3) x 10(4) M-1 s(-1), respectively.