Reaction Kinetics and Catalysis Letters, Vol.86, No.2, 323-329, 2005
Hydrogenation of methyl 3 alpha-acetoxy-23-oxo-5 beta-cholan-24-oate catalyzed by cinchona alkaloid-modified Pt-alumina catalyst
Methyl-3 alpha-acetoxy-23-oxo-5 beta-cholan-24-oate is hydrogenated with 78% enantioselection at C23 atom over Pt-alumina catalyst modified with cinchona alkaloids, in liquid phase under mild experimental conditions (293-297 K, hydrogen pressure: 1 bar, concentration of modifiers: 0.1 mmol/L, solvent: THF).