Reaction Kinetics and Catalysis Letters, Vol.87, No.1, 11-18, 2005
Feasibility and uniqueness of stationary states of nonideal recombinant fermentations
In recombinant fermentations the plasmid loss probability per generation depends on the specific growth rate, which is related linearly to the dilution rate. A model with this feature and incomplete mixing has been studied analytically for stationary state behavior. While the kinetic parameters place upper limits on the dilution rate for a feasible stationary state in a well-mixed bioreactor, the feasible and nonfeasible regions for an incompletely mixed reactor are separated by either a straight line or a plane, whose position is determined by the mixing conditions.
Keywords:continuous fermentation;recombinant bacteria;variable plasmid loss;fluid mixing;stationary states