A series of hydrocracking catalysts based on mesoporous molecular sieves MCM-41 and SBA-15 with different silica to alumina ratios was prepared. Nickel and molybdenum were used as active metals to impregnate the extrudates prepared by using molecular sieves. The catalysts were characterized for physical and chemical properties and evaluated for the hydrocraking of desulfurised vacuum gas oil. The conversion of DS-VGO was lower as compared to that of the catalyst based on USY zeolite. However, the gas yield was lower in case of mesoporous materials based catalysts.