3-alkoxy-5-isoxazolidinones mimic beta-lactams

Cao XF; Iqbal A; Patel A; Gretz P; Huang G; Crowder M; Day RA

Biochemical and Biophysical Research Communications, Vol.311, No.2, 267-271, 2003

DOI10.1016/j.bbrc.2003.09.210 Export Citation

3-alkoxy-5-isoxazolidinones mimic beta-lactams

Cao XF, Iqbal A, Patel A, Gretz P, Huang G, Crowder M, Day RA

3-Alkoxy-5-isoxazolidinones mimic the action of beta-lactams. They bind to the penicillin-binding proteins. They inhibit Class A, Class B, and Class D beta-lactams. They inhibit the growth of Bacillus subtilis. We give a novel synthesis for these compounds. (C) 2003 Elsevier Inc. All rights reserved.

Keywords:5-isoxazolidinone;3-alkoxy-5-isoxazolidinone;beta-lactam mimics;beta-lactamase inhibition;penicillin-binding proteins