Multilayer biogenic capsules with a micrometer scale were fabricated by self-assembly of proteins and lipids at the interface of emulsion droplets. The optical microscopy images demonstrate that spherical capsules at a fluid interface have uniform walls and the dried capsules possess a high mechanical strength. The hollow shells obtained provide a novel class of assembly with encapsulating drug molecules based on the layer-by-layer technique. (C) 2004 Elsevier Inc. All rights reserved.