Binding of the mammalian homolog of the Drosophila discs large tumor suppressor protein to the ribosome receptor

Kim M; Ogawa H; Kohu K; Ichikawa M; Satoh K; Ishidao T; Nada S; Akiyama T

Biochemical and Biophysical Research Communications, Vol.294, No.5, 1151-1154, 2002

DOI10.1016/S0006-291X(02)00600-9 Export Citation

Binding of the mammalian homolog of the Drosophila discs large tumor suppressor protein to the ribosome receptor

Kim M, Ogawa H, Kohu K, Ichikawa M, Satoh K, Ishidao T, Nada S, Akiyama T

DLG, the mammalian homolog of the Drosophila Discs Large suppressor protein, functions as a scaffolding protein that facilitates the transmission of diverse downstream signals. In the present study, we attempted to identify partner proteins for DLG, and found that DLG interacts through its PDZ domains with the ribosome receptor. The ribosome receptor is an integral endoplasmic reticulum protein that has been suggested to be involved in secretion. Our finding raises the possibility that DLG plays a role in the regulation of secretion by interacting with the ribosome receptor. (C) 2002 Elsevier Science (USA). All rights reserved.