Electrophoresis, Vol.22, No.15, 3198-3202, 2001
Chiral separation of pharmacologically active dihydropyrimidinones with carboxymethyl-beta-cyclodextrin
We report on the chiral separation of pharmacologically active dihydropyrimidinones by capillary electrophoresis (CE) using carboxymethyl-beta -cyclodextrin as chiral selector. The influence of selector concentration, pH, and the addition of varying amounts of methanol is investigated. Out of 21 compounds investigated, 19 were resolved, 13 with baseline separation.*
Keywords:dihydropyrimidinones;capillary zone electrophoresis;enantiomer separation;carboxymethyl-beta-cyclodextrin