If fuel cells are introduced for vehicular applications, hydrogen might become an energy carrier for transport applications. Manufacture via steam-reforming of natural gas is a low-cost option for hydrogen production. This study deals with the feasibility of combining the production of hydrogen from natural gas with CO2 removal. When hydrogen is produced from natural gas, a concentrated stream of CO2 is generated as a by-product. If manufacture is carried out near a depleted natural gas field, the separated CO2 can be compressed and injected into the field and securely sequestered there. The incremental cost of the produced hydrogen (for CO2 compression plus transport, injection and storage) would typically be about 7% relative to the case where the separated CO2 is vented. Moreover, CO2 injection leads to enhanced natural gas recovery as a result of reservoir repressurization. Though the extra natural gas is somewhat contaminated with CO2, it is a suitable feedstock for hydrogen production. Taking credit for enhanced natural gas recovery reduces the penalty for sequestration to a net incremental cost of typically 2%. These cost penalties are much lower than those typical of CO2 removal schemes associated with electricity production. Attention is required for optimum plant siting in order to keep CO2 transport costs low.