Phospholipids were successfully micronized. Supercritical antisolvent precipitation (SAS) process was efficient in a wide range of experimental conditions. Amorphous spherical and aggregated particles (from 1 to 40 mum) were obtained by spraying lecithin and ethyl alcohol solutions into flowing supercritical carbon dioxide. The increase of the solute concentration and solution flow rate had a marked influence upon the particle size, while pressure did not seem to have any effect. (C) 2000 Elsevier Science B.V. All rights reserved.