Optimization of synthesizing leucine-binding nano-sized magnetite by a two-step transformation

Dong-Geun Lee; Youn-Sang Bae; Shao-Long Tie; Mir Kim; Ik-Sung Ahn; Chang-Ha Lee

Korean Journal of Chemical Engineering, Vol.25, No.1, 144-148, January, 2008

DOI10.1007/s11814-008-0026-1 Export Citation

Optimization of synthesizing leucine-binding nano-sized magnetite by a two-step transformation

Dong-Geun Lee¹, Youn-Sang Bae¹, Shao-Long Tie^{1, 2}, Mir Kim¹, Ik-Sung Ahn¹, and Chang-Ha Lee^{1, †}

¹Department of Chemical Engineering, Yonsei University, 134 Shinchon-dong, Seodaemun-gu, Seoul 120-749, Korea
²Department of Chemistry, South China Normal University, Guangzhou 510631, P.R.China

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The optimum conditions for synthesizing leucine (Leu)-binding nano-sized magnetite (NSM) particles by a two-step transformation (TST) process were studied. The formation and magnetization of as-synthesized NSM particles were investigated through variation of the acidity, the type of surface modifier, and the nature of the acid for pH adjustment. With increased acidity, the saturation magnetization of the NSM particles decreased, but the amount of Leu coated on the surface of NSM particles increased. After the influence of hydroxyl (OH.) groups on the surface of NSM particles was removed by using the dicarboxyl anion (C2O42.) as a ligand in the first step, Leu was successfully bound with NSM particles in the second step. However, when polyethylene glycol (PEG) was used as a surface modifier, it was difficult to form the Leu-to-NSM particle complex. In terms of the acid used to modify pH, H2SO4 was slightly less effective than HCl in achieving saturation magnetization because the coordination for SO42. anions is stronger than that of Cl. anions. The preparation of other amino acid-binding NSM particles can be optimized in an analogous manner.

Keywords:Magnetite;Two-step transformation;Leucine;Amino acid;Nano-sized particle

[References]

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Tie SL, Lee HC, Bae YS, Kim MB, Lee K, Lee CH, Colloids Surf. A: Physicochem. Eng. Asp., 293, 278 (2007)
Berry CC, Curtis ASG, J. Phys. D-Appl. Phys., 36, R198 (2003)
Arakaki A, Webb J, Matsunaga T, J. Biol. Chem., 278, 8745 (2003)
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Wilson KS, Harris LA, Goff JD, Riffle JS, Dailey JP, European Cells and Materials, 3, 206 (2002)
Igartua M, Saulnier P, Heurtault B, Pech B, Proust JE, Pedraz JL, Benoit JP, Int. J. Pharm., 233, 149 (2002)
Jordan A, Scholz R, Maier-Hauff K, Johannsen M, Wust P, Nadobny J, Schirra H, Schmidt H, Deger S, Loening S, Lanksch W, Felix R, J. Magn. Magn. Mater., 225, 118 (2001)
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Evoy D, Lieberman M, Fahey TJ, Daly JM, Nutrition, 14, 611 (1998)
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Bica D, Vekas L, Rasa M, J. Magn. Magn. Mater., 252, 10 (2002)
Liu XY, Ding XB, Zheng ZH, Peng YX, Chan ASC, Yip CW, Long XP, Polym. Int., 52, 235 (2003)
Ma M, Zhang Y, Yu W, Shen HY, Zhang HQ, Gu N, Colloids Surf. A: Physicochem. Eng. Asp., 212, 219 (2003)
Deng JG, Ding XB, Zhang WC, Peng YX, Wang JH, Long XP, Li P, Chan ASC, Polymer, 43(8), 2179 (2002)
Morais PC, da Silva SW, Soler MAG, Buske N, Biomol. Eng., 17, 49 (2001)
Sousa MH, Tourinho FA, Rubim JC, J. Raman Spectrosc., 31, 185 (2000)
Sahoo Y, Pizem H, Fried T, Golodnitsky D, Burstein L, Sukenik CN, Markovich G, Langmuir, 17(25), 7907 (2001)
Hou Y, Yu J, Gao S, J. Mater. Chem., 13, 1983 (2003)
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Nelson DL, Cox MM, in Principles of biochemistry, in Principles of biochemistry,, 118 (2000)
Nara M, Torii H, Tasumi M, J. Phys. Chem., 100(51), 19812 (1996)

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[3] Berry CC, Curtis ASG, J. Phys. D-Appl. Phys., 36, R198 (2003)

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[7] Yoza B, Arakaki A, Maruyama K, Takeyama H, Matsunaga T, J. Biosci. Bioeng., 95, 21 (2003)

[8] Rousseau V, Pouliquen D, Darcel F, Jallet P, Jeune JJL, Magn. Reson. Mater. Bio. Phys. Med., 6, 13 (1998)

[9] Wilson KS, Harris LA, Goff JD, Riffle JS, Dailey JP, European Cells and Materials, 3, 206 (2002)

[10] Igartua M, Saulnier P, Heurtault B, Pech B, Proust JE, Pedraz JL, Benoit JP, Int. J. Pharm., 233, 149 (2002)

[11] Jordan A, Scholz R, Maier-Hauff K, Johannsen M, Wust P, Nadobny J, Schirra H, Schmidt H, Deger S, Loening S, Lanksch W, Felix R, J. Magn. Magn. Mater., 225, 118 (2001)

[12] Gravinaa PP, Santosa JS, Figueiredoa LC, Netoa KS, Silvaa MFD, Buskec N, Gansauc C, Moraisa PC, J. Magn. Magn. Mater., 252, 393 (2002)

[13] Tallberg T, J. Aust. Coll. Nutr. Environ. Med., 22, 3 (2003)

[14] Ventrucci1 G, de Mello MAR, Cristina M, Gomes-Marcondes C, BMC Cancer, 2, 7 (2002)

[15] Evoy D, Lieberman M, Fahey TJ, Daly JM, Nutrition, 14, 611 (1998)

[16] Ramirez LP, Landfester K, Macromol. Chem. Phys., 204, 22 (2003)

[17] Bica D, Vekas L, Rasa M, J. Magn. Magn. Mater., 252, 10 (2002)

[18] Liu XY, Ding XB, Zheng ZH, Peng YX, Chan ASC, Yip CW, Long XP, Polym. Int., 52, 235 (2003)

[19] Ma M, Zhang Y, Yu W, Shen HY, Zhang HQ, Gu N, Colloids Surf. A: Physicochem. Eng. Asp., 212, 219 (2003)

[20] Deng JG, Ding XB, Zhang WC, Peng YX, Wang JH, Long XP, Li P, Chan ASC, Polymer, 43(8), 2179 (2002)

[21] Morais PC, da Silva SW, Soler MAG, Buske N, Biomol. Eng., 17, 49 (2001)

[22] Sousa MH, Tourinho FA, Rubim JC, J. Raman Spectrosc., 31, 185 (2000)

[23] Sahoo Y, Pizem H, Fried T, Golodnitsky D, Burstein L, Sukenik CN, Markovich G, Langmuir, 17(25), 7907 (2001)

[24] Hou Y, Yu J, Gao S, J. Mater. Chem., 13, 1983 (2003)

[25] Kazuo, in Nakamoto. Infrared and raman spectra of inorganic and coordination compounds, 232, 245, 477, 478, Wiley-Interscience Publication (1986)

[26] Nelson DL, Cox MM, in Principles of biochemistry, in Principles of biochemistry,, 118 (2000)

[27] Nara M, Torii H, Tasumi M, J. Phys. Chem., 100(51), 19812 (1996)