Polymer(Korea), Vol.18, No.1, 113-118, January, 1994
이온성 고분자 겔(Ⅱ) : pH에 민감한 약물전달 체계로의 응용
Polyelectrolyte Gels(Ⅱ) : Application as a pH-Sensitive Drug Delivery System
초록
본 연구에서는 이온성 고분자 겔의 pH에 민감한 약물전달 체계로서의 응용 가능성을 조사하였다. 2-Acrylamido-2-methyl-1-propane sulfonic acid와 Butyl methacrylate의 불규칙 공중합체 겔 네트웍 및 Acrylamide과 2-Acrylamido-2-methyl-1-propane sulfonic acid의 IPNs 겔 네트웍을 이용하였다. 모델 약물로 사용한 하이드로 코티손과 염화에드로포니움은 분산 및 이은교환 수지 방법을 사용하여 겔 네크웍에 충진하였다. 약물 방출 형태는 약물이 충진되어 있는 겐 네트웍의 pH에 의존하는 수팽윤 형태와 약물이 겔 네트웍에 충진되어 있는 형태에 밀접한 상관관계를 나타내었다.
In this study, the feasibility of the application of polyelectrolyte gel network as a pH-sensitive drug delivery system was examined. Copolymer of 2-acrylamido-2-methyl-1-propane sulfonic acid(AMPSA) and butyl methacrylate(BMA) was prepared as random copolymer network(RCN) and that of acrylamide (AAm) and AMPSA was prepared as interpenetrating networks(IPNs) . Hydrocortisone and edrophonium chloride were used as model drugs and were loaded into gel networks using dispersion and ion exchange methods, respectively. The drug release patterns were closely related to the pH-dependent swelling behaviors of gel networks and the mode of drug loading.
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