화학공학소재연구정보센터
Journal of the American Chemical Society, Vol.129, No.48, 14860-14860, 2007
Palladium-catalyzed decarboxylative sp(3)-sp(3) coupling of nitrobenzene acetic esters
Allylic esters of nitrobenzene acetic acids undergo facile palladium-catalyzed decarboxylative coupling. Both mono- and dinitroarene substrates give high yields of the coupled products. Moreover, the rates of the reactions suggest that decarboxylation is rate-limiting and substrates that sterically disfavor attainment of the reactive conformation for decarboxylation are not viable. Finally, reduction of the product nitroarenes to the corresponding anilines provides access to a variety of heterocycles including quinolines and dihydroquinolones.