Kinetic analysis of macromolecular conversion has many difficulties such as definition of rate of conversion and molecular-weight determination. Continuous-distribution kinetic analysis has been proposed for kinetic evaluation of asphaltene hydrocracking. Asphaltene has the molecular-weight distribution (MWD) spanning continuously in the wide range, A gel permeation chromatography (GPC) is a practical and convenient method to observe MWDs of reaction mixtures during the conversion, A mathematical model was presented using simple schemes of chemical reactions representing overall reactions to interpret experimental results. The weights and MWDs of asphaltene components were converted into the corresponding zeroth moment (molar concentration) and first moment (mass concentration), and the time-dependent changes of these moments gave the apparent kinetic parameters of the overall reactions.