자극감응성 고분자막의 제조와 약물투과특성 :Ⅳ. UV조사법에 의한 폴리아미드막의 기능화와 리보플라빈의 투과특성

임성윤; 심진기; 이영무; 강덕만; 조종수; 박영훈

Polymer(Korea), Vol.18, No.3, 406-411, May, 1994

Preparation of Stimuli-Responsive Polymeric Membranes and Their Permeation Characteristics of Drugs : Ⅳ. Functionalization of Polyamide Membranes Prepared by UV Irradiation Method and Their Riboflavin Permeation

임성윤, 심진기, 이영무, 강덕만, 조종수, 박영훈

초록

폴리아미드 다공성막표면에 자외선을 조사하여 아크릴산과 메타크릴산 _그리고 N-isopropylacylamide(NIPAm)를 그라프트중합하여 pH와 온도변화 및 그라프트 밀도변화에 따른 리보플라빈의 투과도 변화를 고찰하였다. 아크릴산이 그라프트된 막은 pH 4∼5의 범위에서, 메타크릴산이 그라프트된 막은 pH 6∼7의 범위에서 급격한 투과도 감소를 나타내었다. pH 7과 pH 4에서의 투과도의 비는 큰 경우가 1.3 정도였다. NIPAm이 그라프트되면 lower critical solution temperature(LCST)로 인해 약 31∼33℃부근에서 급격한 투과도 증가가 나타났다. 아크릴아미드가 NIPAm과 공중합되면 LCST 전이온도가 40∼50℃로 높아졌다. 기능성 단량체들의 개시방법들에 따른 투과도 및 pH변화를 살펴보았다.

Acrylic acid, methacrylic acid and N-isopropylacrylamide(NIPAm) were grafted onto the porous polyamide membrane using ultraviolet irradiation method. The riboflavin permeation behaviors through the prepared graft membranes were investigated as a function of the change in pH, temperature and the graft density. Acrylic aicd graft membrane showed a rapid decrease in permeability at pH range between 4 and 5, while methacrylic acid graft membrane showed the pH sensitivity in pH 6∼7. The largest ratio of permeability at pH 7 and 4 is about 1.3 for UA-1 and UM-1 membranes. As NIPAm is grafted onto the polyamide membrane, the permeability increased rapidly at 31 ∼33℃ due to the lower critical solution temperature(LCST). As acrylamide is copolymerized with NIPAm, LCST increased to 40∼50℃. We also compared the permeabilities and the pH sensitivities of membranes prepared from the different initiation methods as reported earlier.

[References]

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[1] Zattaroni A, Chemtech., 757 (1980)

[2] Zattaroni A, Chemtech., 82 (1976)

[3] Creque H, Langer R, Folkman J, Diabetes, 35, 684 (1986)

[4] Langer R, Folkman J, Nature, 263, 797 (1976)

[5] Okahata Y, Seki T, Macromolecules, 17, 1880 (1984)

[6] Okahata Y, Noguchi H, Seki T, Macromolecules, 20, 15 (1987)

[7] Kitano H, Akatsuka Y, Ise N, Macromolecules, 24, 42 (1991)

[8] Seigel RA, Falamarzian M, Firestone BA, Moxley BC, J. Control. Release, 8, 179 (1988)

[9] Hoffman S, Dong L, J. Control. Release, 15, 141 (1991)

[10] Klumb LA, Horbett TA, J. Control. Release, 18, 59 (1992)

[11] Kim JH, Kim JY, Lee YM, Kim KY, J. Appl. Polym. Sci., 44, 1823 (1992)

[12] Chung DJ, Ito Y, Imanishi Y, J. Control. Release, 18, 45 (1992)

[13] Okahata Y, Lim HJ, Nakamura G, Hachiya S, J. Am. Chem. Soc., 105, 4855 (1983)

[14] Okano T, Bae YH, Jacobs H, Kim SW, J. Control. Release, 11, 255 (1990)

[15] Okano T, Bae YH, Kim SW, Pharm. Res., 8, 624 (1991)

[16] Ito Y, Kotera S, Ibana M, Kono K, Imanishi Y, Polymer, 31, 2157 (1990)

[17] Iwata H, Matsuda T, J. Membr. Sci., 38, 185 (1988)

[18] Osada Y, Honda K, Ohta M, J. Membr. Sci., 27, 327 (1986)

[19] Kim JH, Lee YM, Jung CN, J. Korean Ind. Eng. Chem., 3(2), 296 (1992)

[20] Ihm SY, Lee YM, Kim JH, Cho CS, Sung YK, Polym.(Korea), 18(3), 391 (1994)

[21] Ihm SY, Lee YM, Kim JH, Kang DM, Cho CS, Sung YK, Polym.(Korea), 18(3), 399 (1994)

[22] Mueller KF, Polymer, 33(16), 3470 (1992)

[23] Gehrke SH, Palasis M, Akhtar MK, Polym. Int., 29, 29 (1992)