The performance of a coaxial mixer equipped with an anchor combined to either a radial or an axial impeller was investigated. The system was operated in both counter- and corotating modes in the laminar and transition flow regimes. Experimental and numerical data regarding power consumption, mixing time, tracer evolution, and flow characterization were collected and compared. On the basis of these mixing efficiency criteria, the corotating mode was found to be a better choice for both mixers in the investigated flow regimes. The axial impeller-anchor mixer was also found to be more efficient in terms of energy consumption and mixing energy compared to the Rushton-anchor configuration.