The purpose of this study is to investigate the various characteristics of a radiant ceiling panel system and their practical application to office buildings. The radiant ceiling panel system and conventional air-conditioning system were compared in terms of thermal comfort, energy consumption, and cost. Thermal environment, along with human response, was tested by using a small meeting room equipped with radiant ceiling panels. The responses were collected by questionnaires given to the male subjects in the room. The experiment for the female subjects was conducted separately. Results show that the radiant ceiling panel system is capable of creating smaller vertical variation of air temperature and a more comfortable environment than conventional systems. When using a cooled ceiling, a small volume of supplied air creates a less draught environment, which reduced the discomfort of feeling cold in the lower part of the body. Numerical simulation of yearly energy consumption and cost estimation were conducted. Typical office rooms located on the 3rd, 4th, and 5th floor of a six-floor building in the Tokyo area were simulated. Since part of the sensible heat load is handled by radiant ceiling panels, the volume of supplied air can be reduced, leading to lower energy consumption for air transport. By using the radiant ceiling panel system in one of the three floors of the simulated building, energy consumption can be reduced by 10%. Estimated pay back time was from 1 to 17 years depending on the market price of the radiant ceiling panel.