The inherent sustainability and low carbon dioxide (CO2) emissions of renewable energy technologies provide the necessary features of future energy policy goals. To secure the contribution of renewables in the future energy supply, practical dynamic optimization strategies for CO2 conversion into methanol in a heterogeneous reactor are proposed. The conversion provides a solution to the problem of carbon dioxide emissions reduction and at the same time produces a readily storable and transportable fuel. The dynamic optimization is carried out on an industrial scale methanol reactor and considers shell temperature and inlet hydrogen mole fraction, separately and simultaneously, as optimization variables. The optimizations have been carried out in both steady- and unsteady-state modes. A heterogeneous model of the reactor has been used to obtain accurate optimization results. In the dynamic mode, a stagewise optimization for 4 years of reactor operation has been considered. The methanol production rate (MPR) has been selected as the objective function to find optimal profiles. In the steady-state case, the optimal input mole fractions Of CO, CO2, and H-2 have been investigated. The calculated concentration profiles are realistic and appropriate for the application of an industrial methanol reactor. The staged optimization suggests a new guideline for operating the reactor. For the optimization of input mole fractions, it was indirectly concluded that CO2 concentration adversely affects the overall process as compared to catalyst poisoning due to the presence of CO.