Chemistry Letters, Vol.36, No.7, 942-943, 2007
Cation-exchange resin as efficient, cost-effective and recyclable catalyst for the synthesis of 3-propargylindoles
Indoles undergo smooth alkylation with propargylic acetates in the presence of Amberlyst A-15 (R) under mild conditions to produce 3-propargylated indoles in excellent yields with high selectivity. This is the first example for the alkylation of indoles with propargylic acetates using the acid catalyst.