Flavoprotein monoamine oxidase is located on the outer membrane of mitochondria. It catalyzes oxidative deamination of monoamine neurotransmitters such as serotonin, norepinephrine and dopamine and hence is a target enzyme for antidepressant drugs. MAO ( mono amine oxidase) has two isoforms, namely MAO- A and MAO- B. MAO- A isoform has higher affinity for serotonin and norepinephrine, while; MAO- B preferentially deaminates phenylethylamine and benzylamine. These important properties determine the clinical importance of MAO inhibitors. Selective MAO- A inhibitors are used in the treatment of neurological disorders such as depression. In this article we have developed a Hypogen pharmacophore for a set of 64 coumarin analogs and tried to analyze the intermolecular H- bonds with receptor structure.