Journal of Molecular Catalysis A-Chemical, Vol.272, No.1-2, 128-131, 2007
Organic synthesis in water: Green protocol for the synthesis of 2-amino furan derivatives
Aldehyde, dimethyl acetylenedicarboxylate (DMAD) and cyclohexyl isocyanide undergo smooth coupling in water to produce the corresponding 2-aminofuran derivatives in good yields. Water helps to avoid the use of highly toxic and environmentally unfavorable solvents for this conversion. (c) 2007 Elsevier B.V. All rights reserved.