A new efficient covalent immobilization method for preparation of silica-grafted poly-(L)-leucine catalyst AP-PLL-Silica gel was developed. The AP-PLL-Silica gel catalyzed asymmetric epoxidation of benzalacetophenone, yielding optically active epoxy ketone in high enantioselectivity up to 97% e.e. The catalyst was easily separated and reused several times with DO significant loss of activity and enantio selectivity. (C) 2007 Elsevier B.V. All rights reserved.