Treated domestic secondary effluent is a valuable water source that can be reused for diverse purposes. However, in order to minimize health and environmental risks and to maintain adequate levels of sustainable agriculture production on a long range time scale, advanced treatment is required. Advanced effluent quality maintaining minimal risks can be primarily attained by implementing the membrane technology. Field experiments are in progress for secondary wastewater polishing for unrestricted reuse for sustainable agricultural production. The two stage membrane treatment system for the secondary effluent polishing consists of combining two main stages: ultrafiltration (UF) and reverse osmosis (RO) membrane treatment. The UF stage is efficient in the removal of the organic matter and the pathogens while the RO provides the dissolved solids (salinity) removal. Effluent of various qualities is applied for irrigation along with continuous monitoring of the membrane components performance. The experimental data was obtained in the ongoing pilot studies carried out near the City of Arad (Israel) wastewater treatment system (the pilot plant performs in a feed and bleed operation mode). The results indicate the importance of maintaining high quality effluent for sustainable agriculture production. The management modeling gives an idea of the importance in maintaining adequate UF flushing policy in order to minimize expenses due to fouling.