GspE is an important component of the type II secretion system (T2SS) in Gram-negative bacteria that supplies energy for the process of protein secretion. The role of GspE and its interactions with other components have been intensively studied. However, regulation of the gspE gene is poorly understood. In this study, we demonstrated that the transcription of xpsE, a homologue of gspE in Xanthomonas campestris pathovar campestris (Xcc), is upregulated by Clp, a homologue of the cyclic AMP-receptor protein, by directly binding to the xpsE promoter region. Overexpression of the clp gene in Xcc wild-type strain 8004 enhanced the production of XpsE as well as endoglucanase and extracellular polysaccharide (EPS).