New gold catalytic system prepared on ceria-modified mesoporous titania (CeMTi) used as water-gas shift (WGS) reaction catalyst is reported. Mesoporous titania (MTi) was synthesized using surfactant templating method through a neutral [C-13(EO)(6)-Ti(OC3H7)(4)] assembly pathway. Ceria modifying additive was deposited on MTi by deposition precipitation (DP) method. Gold-based catalysts with different gold content (1-5 wt.%) were synthesized by DP of gold hydroxide on mixed metal oxide support. The supports and the catalysts were characterized by powder X-ray diffraction (XRD), high-resolution transmission electron microscopy (HRTEM), N-2 adsorption analysis and temperature-programmed reduction (TPR). The catalytic behavior of the gold-based catalysts was evaluated in WGS reaction in a wide temperature range (140-300 degrees C) and at different space velocities and H2O/CO ratios. The influence of gold content and particle size on the catalytic performance was investigated. The WGS activity of the new gold/ceria-modified mesoporous titania catalysts was compared with that of gold catalysts supported on simple oxides CeO2 and mesoporous TiO2, as well as gold/ceria-modified titania and reference catalyst Au/TiO2 type A (World Gold Council). A high degree of synergistic interaction between ceria and mesoporous titania and a positive modification of structural and catalytic properties by ceria has been achieved. It is clearly revealed that the ceria-modified mesoporous titania is of much interest as potential support for gold-based catalyst. The Au/ceria-modified mesoporous titania catalytic system is found to be efficient catalyst for WGSR. (c) 2007 Elsevier B.V. All rights reserved.