The interplay between chemistry and interfacial-tension-driven hydrodynamic instabilities has been studied experimentally. The system on hand consists of two immiscible liquids separated along an initially plane interface at which an interfacial reaction takes place to produce in situ a surfactant. It is identified that the dynamics of the system depends on the orientation of the Hele-Shaw cell with respect to the vector of gravity. If the Hele-Shaw cell is placed vertically, Marangoni cells with vigorous convection develop in both phases along a nearly planar interface. However, if the Hele-Shaw cell is tilted off the gravity, the instabilities in the system are characterized by the large scale interfacial deformation with a spatio-temporal periodicity together with the chemo-Marangoni convection. The focus on the exploration of the transition from the cellular mode to the large scale interfacial deformation.