Antimicrobial Drug Release Scaffolds of Natural and Synthetic Biodegradable Polymers

Periasamy Prabu; Kwan Woo Kim; Nallusamy Dharmaraj; Jong Hoon Park; Myung Seob Khil; Hak Yong Kim

Macromolecular Research, Vol.16, No.4, 303-307, June, 2008

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Antimicrobial Drug Release Scaffolds of Natural and Synthetic Biodegradable Polymers

Periasamy Prabu, Kwan Woo Kim, Nallusamy Dharmaraj¹, Jong Hoon Park², Myung Seob Khil², and Hak Yong Kim^{2, †}

Department of Bionanosystem Engineering, Chonbuk National University, Jeonju 561-756, Korea
¹Department of Chemistry, Bharathiar University, Coimbatore 641046, India
²Department of Textile Engineering, Chonbuk National University, Jeonju 561-756, Korea

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A series of biodegradable polymeric scaffolds was prepared by using a combination of natural (collagen) and synthetic (poly(caprolactone)) (PCL) polymers in various compositions. These scaffolds were soft, spongy, porous and transparent in nature and were characterized by thermogravimetric analysis (TGA) and Fourier transform infrared (FT-IR) spectroscopy. The entrapment efficiency and drug release activity of the scaffolds were analyzed using penicillin and tetracycline as antimicrobial drugs. The drug release activity of the scaffolds with various combinations of collagen and PCL were studied by measuring the optical density in a spectrophotometer at the following time intervals: 1, 4, 24, 48 and 60 h. These scaffolds showed better and continuous drug release for up to 60 h. Even after such a long duration, a portion of the drug remained entrapped in the scaffolds, indicating that they can be utilized for wound healing applications.

Keywords:biodegradable polymers;poly(caprolactone);collagen;scaffolds;penicillin;tetracycline

[References]

Chen WY, Abatangelo G, Wound Repair Regen., 7, 79 (1999)
Miclau T, Edin ML, Lester FE, Lindsey RW, Daheners LE, J. Orthop. Tramuma., 9, 401 (1995)
Lee JS, Kim JK, Park SR, Chang YH, Macromol. Res., 15(3), 205 (2007)
Pitt CG, in Biodegradable Polymers as Drug Delivery Systems, M. Chasin and R. Langer, Eds., Marcel Dekker, New York, 1990, pp. 71-120 (1990)
Kim SW, Bae HK, Nam HS, Chung DJ, Choung PH, Macromol. Res., 14(1), 94 (2006)
Saltzman MW, Baldwin SP, Adv. Drug. Deliver. Rev., 33, 71 (1998)
Sohier J, Haan RE, Groot K, Bezemer JM, J. Control. Release, 87, 57 (2003)
Beonit MA, Baras B, Gillard J, Int. J. Pharm., 184, 73 (1999)
Sivakumar M, Rao KP, Biomaterials, 23, 3175 (2002)
Komlev VS, Barinov SM, Koplik EV, Biomaterials, 23, 3449 (2002)
Krajewski A, Ravaglioli A, Roncari E, Pinsco P, Montanari L, J. Mater. Sci. -Mater. Med., 11, 763 (2000)
Kim HW, Knowles JC, Kim HE, Biomaterials, 25, 1279 (2004)
Boyce ST, Supp AP, Warden GD, Holder IA, Antimicrob. Agents Chemother., 37, 1890 (1993)
Grzybowski J, Kolodziej W, Trafny EA, Struzyna J, J. Biomed. Mater. Res., 36, 163 (1997)
Sripriya R, Ahmed MR, Sehgal PK, Jayakumar R, J. Appl. Polym. Sci., 87(13), 2186 (2003)
Sakeil S, Grzybowski J, Polym. Med., 25, 19 (1995)

[Referenced By]

[Related Articles]

[1] Chen WY, Abatangelo G, Wound Repair Regen., 7, 79 (1999)

[2] Miclau T, Edin ML, Lester FE, Lindsey RW, Daheners LE, J. Orthop. Tramuma., 9, 401 (1995)

[3] Lee JS, Kim JK, Park SR, Chang YH, Macromol. Res., 15(3), 205 (2007)

[4] Pitt CG, in Biodegradable Polymers as Drug Delivery Systems, M. Chasin and R. Langer, Eds., Marcel Dekker, New York, 1990, pp. 71-120 (1990)

[5] Kim SW, Bae HK, Nam HS, Chung DJ, Choung PH, Macromol. Res., 14(1), 94 (2006)

[6] Saltzman MW, Baldwin SP, Adv. Drug. Deliver. Rev., 33, 71 (1998)

[7] Sohier J, Haan RE, Groot K, Bezemer JM, J. Control. Release, 87, 57 (2003)

[8] Beonit MA, Baras B, Gillard J, Int. J. Pharm., 184, 73 (1999)

[9] Sivakumar M, Rao KP, Biomaterials, 23, 3175 (2002)

[10] Komlev VS, Barinov SM, Koplik EV, Biomaterials, 23, 3449 (2002)

[11] Krajewski A, Ravaglioli A, Roncari E, Pinsco P, Montanari L, J. Mater. Sci. -Mater. Med., 11, 763 (2000)

[12] Kim HW, Knowles JC, Kim HE, Biomaterials, 25, 1279 (2004)

[13] Boyce ST, Supp AP, Warden GD, Holder IA, Antimicrob. Agents Chemother., 37, 1890 (1993)

[14] Grzybowski J, Kolodziej W, Trafny EA, Struzyna J, J. Biomed. Mater. Res., 36, 163 (1997)

[15] Sripriya R, Ahmed MR, Sehgal PK, Jayakumar R, J. Appl. Polym. Sci., 87(13), 2186 (2003)

[16] Sakeil S, Grzybowski J, Polym. Med., 25, 19 (1995)