초임계이산화탄소내 트리클로산의 용해도와 미세입자 제조공정의 응용

신문삼; 김화용; Moon Sam Shin; Hwayong Kim

Clean Technology, Vol.14, No.3, 153-159, September, 2008

Export Citation

초임계이산화탄소내 트리클로산의 용해도와 미세입자 제조공정의 응용

Solubility of Triclosan in Supercritical Carbon Dioxide and its Application to Micronization Process

신문삼, 김화용 ^†

서울대학교 화학생물공학부, 151-744 서울시 관악구 신림동 산56-1

Moon Sam Shin, and Hwayong Kim^†

School of Chemical and Biological Engineering, Seoul National University, San 56-1, Shinlim-dong, Gwanak-gu, Seoul 151-744, Korea

E-mail:

초록

여드름 치료제인 트리클로산의 초임계이산화탄소에 대한 용해도를 가변부피셀(Variable volume cell)을 이용하여 온도 313.15, 323.15와 333.15 K에 대해서 10 . 40 MPa 압력범위에서 측정되었다. QLF (Quasichemical nonrandom lattice fluid) 상태방정식을 이용하여 측정된 용해도를 잘 계산할 수 있었고, 이 자료를 미세입자공정에 활용하였고, 입자크기에 미치는 온도와 압력의 효과를 해석하였다.

The solubility of triclosan, an anti-acne agent was measured in supercritical carbon dioxide (scCO2) with a variable volume view cell at 313.15, 323.15, and 333.15 K and at pressures between 10 and 40 MPa. We successfully correlated triclosan solubility in scCO2 using the quasi-chemical nonrandom lattice fluid (QLF) equation of state. Triclosan was micronized using the rapid expansion of supercritical solutions (RESS) process. The effects of temperature and pressure on particle size were investigated using phase behavior data and correlated results from the QLF model.

Keywords:Triclosan;Supercritical fluids;Carbon dioxide;Solubility;Micronized particles

[References]

Teja AS, Eckert CA, Ind. Eng. Chem. Res., 39, 4442 (2000)
Jung J, Perrut M, J. Supercrit. Fluids, 20(3), 179 (2001)
Knez Z, Weinder E, Appl. Chem., 7, 353 (2003)
Kayrak D, Akman U, Hortacsu O, J. Supercrit. Fluids, 26(1), 17 (2003)
Beckman EJ, J. Supercrit. Fluids, 28(2-3), 121 (2004)
Huang Z, Sun GB, Chiew YC, Kawi S, Powder Technol., 160(2), 127 (2005)
Howard M, "Pharmaceutical Compositions and Methods for Managing Skin Conditions," U.S. Patent No. 7,018,660 (2006)
Heath RJ, Rubin JR, Holland DR, Zhang E, Show ME, Rock CO, J. Biol. Chem., 274, 11110 (1999)
Peng DY, Robinson DB, Ind. Eng. Chem. Fundam., 15, 59 (1976)
Shin MS, Kim H, Fluid Phase Equilib., 246(1-2), 79 (2006)
Shin MS, Kim H, Fluid Phase Equilib., 256(1-2), 27 (2007)
Shin MS, Kim H, Fluid Phase Equilibr., 270, 45 (2008)
Bae W, Kwon SY, Byun HS, Kim HY, J. Supercrit. Fluids, 30(2), 127 (2004)
Shin J, Shin MS, Bae W, Lee YW, Kim H, J. Supercrit. Fluids, 44, 260 (2008)
Joback KG, Reid RC, Chem. Eng. Comm., 57, 233 (1987)
Stein SE, Brown RL, J. Chem. Inf. Comput.Sci., 34, 581 (1994)
Lyman WJ, Reehl WF, Rosenblatt DH, Handbook of Chemical and Physical Property Estimation Methods: Environmental Behavior of Organic Compounds, American Chemical Society, Washington, D.C. (1990)
Fedors RF, Polym. Eng.Sci., 14, 147 (1974)
Kang J, Yoo KP, Kim H, Lee J, Yang D, Lee CS, Int. J. Thermophys., 22, 487 (2001)

[Referenced By]

[Related Articles]

[1] Teja AS, Eckert CA, Ind. Eng. Chem. Res., 39, 4442 (2000)

[2] Jung J, Perrut M, J. Supercrit. Fluids, 20(3), 179 (2001)

[3] Knez Z, Weinder E, Appl. Chem., 7, 353 (2003)

[4] Kayrak D, Akman U, Hortacsu O, J. Supercrit. Fluids, 26(1), 17 (2003)

[5] Beckman EJ, J. Supercrit. Fluids, 28(2-3), 121 (2004)

[6] Huang Z, Sun GB, Chiew YC, Kawi S, Powder Technol., 160(2), 127 (2005)

[7] Howard M, "Pharmaceutical Compositions and Methods for Managing Skin Conditions," U.S. Patent No. 7,018,660 (2006)

[8] Heath RJ, Rubin JR, Holland DR, Zhang E, Show ME, Rock CO, J. Biol. Chem., 274, 11110 (1999)

[9] Peng DY, Robinson DB, Ind. Eng. Chem. Fundam., 15, 59 (1976)

[10] Shin MS, Kim H, Fluid Phase Equilib., 246(1-2), 79 (2006)

[11] Shin MS, Kim H, Fluid Phase Equilib., 256(1-2), 27 (2007)

[12] Shin MS, Kim H, Fluid Phase Equilibr., 270, 45 (2008)

[13] Bae W, Kwon SY, Byun HS, Kim HY, J. Supercrit. Fluids, 30(2), 127 (2004)

[14] Shin J, Shin MS, Bae W, Lee YW, Kim H, J. Supercrit. Fluids, 44, 260 (2008)

[15] Joback KG, Reid RC, Chem. Eng. Comm., 57, 233 (1987)

[16] Stein SE, Brown RL, J. Chem. Inf. Comput.Sci., 34, 581 (1994)

[17] Lyman WJ, Reehl WF, Rosenblatt DH, Handbook of Chemical and Physical Property Estimation Methods: Environmental Behavior of Organic Compounds, American Chemical Society, Washington, D.C. (1990)

[18] Fedors RF, Polym. Eng.Sci., 14, 147 (1974)

[19] Kang J, Yoo KP, Kim H, Lee J, Yang D, Lee CS, Int. J. Thermophys., 22, 487 (2001)