Temperature-Induced Release of All-trans-Retinoic Acid Loaded in Solid Lipid Nanoparticles for Topical Delivery

Chang-Moon Lee; Hwan-Jeong Jeong; Ji-Won Park; Jin Kim; Ki-Young Lee

Macromolecular Research, Vol.16, No.8, 682-685, December, 2008

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Temperature-Induced Release of All-trans-Retinoic Acid Loaded in Solid Lipid Nanoparticles for Topical Delivery

Chang-Moon Lee, Hwan-Jeong Jeong, Ji-Won Park¹, Jin Kim², and Ki-Young Lee^{3, †}

Department of Nuclear Medicine, Research Institute of Clinical Medicine, Institute for Medical Sciences, Chonbuk National University Medical School, Jeonju, Jellabuk-Do 561-712, Korea
¹Interdisciplinary Program of Perfume and Cosmetics, Chonnam National University, Gwangju 500-757, Korea
²Department of Advanced Chemicals, Chonnam National University, Gwangju 500-757, Korea
³Faculty of Chemical Engineering, Chonnam National University, Gwangju 500-757, Korea

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The aim of this work was to develop and evaluate solid lipid nanoparticles (SLN) containing all-transretinoic acid (ATRA) for topical delivery. SLN composed of coconut oil and curdlan improved the suspension instability of ATRA in aqueous solution. The photodegradation of ATRA by light was reduced by incorporation in SLN. The loading efficiency of ATRA in SLN was higher than 95% (w/w). The amounts of ATRA released from SLN at 4 ℃ and at 37 ℃ were less than 15% and more than 60% (w/w) for 96 h, respectively. The ATRA-loaded SLN can be used as a potential carrier for topical delivery.

Keywords:all-trans-retinoic acid;coconut oil;curdlan;solid lipid nanoparticle;topical delivery.

[References]

Yamaguchi Y, Nagasawa T, Nakmura N, Takenaga M, Mizoguchi M, Kawai SI, Mizushima Y, Igarashi R, J. Control. Release, 104, 29 (2005)
Klingman AM, Grove GL, Hirose R, Leyden JJ, J. Am. Acad. Dermatol., 15, 836 (1986)
Lehman PA, John JT, Franz TJ, J. Invest. Dermatol., 91, 56 (1990)
Njar VC, Gediya L, Purushottanmachar P, Chopra P, Vasaitis TS, Khandelwal A, Mehta J, Huynh C, Belosay A, Patel J, Bioorg. Med. Chem., 14, 4323 (2006)
Jeong YI, Kim SH, Jung TY, Kim IY, Kang SS, Jin YH, Ryu HH, Sun HS, Jin S, Kim KK, Ahn KY, Jung S, J. Pharm. Sci., 95, 2348 (2006)
Seo SJ, Moon HS, Guo DD, Kim SH, Akaike T, Cho CS, Mater. Sci. Eng. C, 26, 136 (2006)
Kim DG, Choi C, Jeong YI, Jang MK, Nah JW, Kang SK, Bang MS, Macromol. Res., 14(1), 66 (2006)
Park JS, Koh YS, Bang JY, Jeong YI, Lee JJ, J. Pharm. Sci., 97, Articles online in advance of print (2008)
Na K, Park KH, Kim SW, Bae YH, J. Control. Release, 69, 225 (2000)
Brisaert M, Plaizier-Vercammen JA, Int. J. Pharm., 334, 56 (2007)
Hwang SR, Lim SJ, Park JS, Kim CK, Int. J. Pharm., 276, 175 (2004)
Mehnert W, Mader K, Adv. Drug Deliv. Rev., 47, 165 (2001)
Han SC, Kim YZ, Lee KY, Kim DW, Korean J. Biotechnol. Bioeng., 19, 178 (2004)
Kim BD, Na G, Choi HK, Eurp. J. Pharm. Sci., 24, 199 (2005)
Chen H, Chang X, Du D, Liu W, Liu J, Weng T, Yang Y, Xu H, Yang X, J. Control. Release, 110, 296 (2006)
Liu J, Hu W, Chen H, Ni Q, Xu H, Yang X, Int. J. Pharm., 328, 191 (2007)
Shah KA, Date AA, Joshi MD, Patravale VB, Int. J. Pharm., 345, 163 (2007)

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[1] Yamaguchi Y, Nagasawa T, Nakmura N, Takenaga M, Mizoguchi M, Kawai SI, Mizushima Y, Igarashi R, J. Control. Release, 104, 29 (2005)

[2] Klingman AM, Grove GL, Hirose R, Leyden JJ, J. Am. Acad. Dermatol., 15, 836 (1986)

[3] Lehman PA, John JT, Franz TJ, J. Invest. Dermatol., 91, 56 (1990)

[4] Njar VC, Gediya L, Purushottanmachar P, Chopra P, Vasaitis TS, Khandelwal A, Mehta J, Huynh C, Belosay A, Patel J, Bioorg. Med. Chem., 14, 4323 (2006)

[5] Jeong YI, Kim SH, Jung TY, Kim IY, Kang SS, Jin YH, Ryu HH, Sun HS, Jin S, Kim KK, Ahn KY, Jung S, J. Pharm. Sci., 95, 2348 (2006)

[6] Seo SJ, Moon HS, Guo DD, Kim SH, Akaike T, Cho CS, Mater. Sci. Eng. C, 26, 136 (2006)

[7] Kim DG, Choi C, Jeong YI, Jang MK, Nah JW, Kang SK, Bang MS, Macromol. Res., 14(1), 66 (2006)

[8] Park JS, Koh YS, Bang JY, Jeong YI, Lee JJ, J. Pharm. Sci., 97, Articles online in advance of print (2008)

[9] Na K, Park KH, Kim SW, Bae YH, J. Control. Release, 69, 225 (2000)

[10] Brisaert M, Plaizier-Vercammen JA, Int. J. Pharm., 334, 56 (2007)

[11] Hwang SR, Lim SJ, Park JS, Kim CK, Int. J. Pharm., 276, 175 (2004)

[12] Mehnert W, Mader K, Adv. Drug Deliv. Rev., 47, 165 (2001)

[13] Han SC, Kim YZ, Lee KY, Kim DW, Korean J. Biotechnol. Bioeng., 19, 178 (2004)

[14] Kim BD, Na G, Choi HK, Eurp. J. Pharm. Sci., 24, 199 (2005)

[15] Chen H, Chang X, Du D, Liu W, Liu J, Weng T, Yang Y, Xu H, Yang X, J. Control. Release, 110, 296 (2006)

[16] Liu J, Hu W, Chen H, Ni Q, Xu H, Yang X, Int. J. Pharm., 328, 191 (2007)

[17] Shah KA, Date AA, Joshi MD, Patravale VB, Int. J. Pharm., 345, 163 (2007)