Nonlinear isotherm of benzene and its derivatives by frontal analysis

Xiaolong Wan; Ju Weon Lee; Kyung Ho Row

Korean Journal of Chemical Engineering, Vol.26, No.1, 182-188, January, 2009

DOI10.1007/s11814-009-0030-0 Export Citation

Nonlinear isotherm of benzene and its derivatives by frontal analysis

Xiaolong Wan, Ju Weon Lee, and Kyung Ho Row^†

Center for Advanced Bioseparation Technology, Department of Chemical Engineering, Inha University, 253 Yonghyun-dong, Nam-gu, Incheon 402-751, Korea

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Abstract.Adsorption behavior of a solute is one of the most important factors to consider when designing a batch and a continuous liquid chromatographic separation process. In liquid chromatography, this behavior is based on the adsorption equilibrium between the liquid mobile-phase and solid stationary-phase. However, most retention models have been developed under a linear adsorption isotherm: very few researchers have investigated the relationship between the adsorption parameters and the mobile phase composition, and some empirical models have been introduced. In this work, adsorption isotherms were obtained by a frontal analysis for three small molecular compounds (benzene, toluene, and chlorobenzene) on a commercial C18 bonded silica column. The absorption based on the Langmuir, Freundlich, and Langmuir-Freundlich models were investigated according to changes of the composition of methanol highly enriched eluent. The calculations and analysis of the coefficients obtained for the three models confirm that the adsorption data for solutes are best modeled with the Langmuir-Freundlich isotherm. In spite of the acceptable accuracy, Langmuir and Freundlich isotherm models couldn’t satisfactorily describe the mechanism and provide objective information on the physical nature of the absorption.

Keywords:Adsorption Isotherm Modeling;Frontal Analysis;Mobile Phase Composition

[References]

Horvath C, Melander WR, Molnar I, J. Chromatogr. A, 125, 129 (1976)
Dorsey JG, Dill KA, Chemical Reviews, 89, 331 (1989)
Gritti F, Guiochon G, J. Chromatogr. A, 1097, 98 (2005)
Snyder LR, Principles of adsorption chromatography, Marcel Dekker, New York (1968)
Poppe H, J. Chromatogr. A, 656, 19 (1993)
Guiochon G, Golshan-Shirazi S, Katti A, Fundamenta1s of preparative and nonlinear chromatography, Academic Press, New York (1994)
Nicoud RM, Seidel-Morgenstern A, Isolation Purif., 2, 165 (1996)
Huber JFK, Gerritse RG, J. Chromatogr. A, 58, 137 (1971)
De Jong AWJ, Kraak JC, Poppe H, Nooitgedacht F, J. Chromatogr. A, 193, 181 (1980)
Jacobson JM, Frenz J, Horvath C, Ind. Eng. Chem. Res., 26, 43 (1987)
Jacobson JM, Frenz J, J. Chromatogr. A, 499, 5 (1990)
Golshan-Shirazi S, Godbane S, Guiochon G, Anal. Chem., 60, 2630 (1988)
Liseca O, Hugob P, Seidel-Morgenstern A, J. Chromatogr. A, 908, 19 (2001)
Seidel A, Tscheutschler E, Radeke KH, Gelbin D, Chem. Eng. Sci., 40, 215 (1985)
Ching CB, Chu KH, Ruthven DM, AIChE J., 36, 275 (1990)
Blumel C, Hugo P, Seidel-Morgenstern A, J. Chromatogr. A, 865, 51 (1999)
Chan K, Jensen NS, Silber PM, O’Brien PJ, Chemico-Biological Interactions, 165, 165 (2007)
Lide DR, CRC handbook of chemistry and physics, 75th ed., Boca Raton, Florida (1994)
Cavazzini A, Bardin G, Kaczmarski K, Szabelski P, Al-Bokari M, Guiochon G, J. Chromatogr. A, 957, 111 (2002)

[Related Articles]

[1] Horvath C, Melander WR, Molnar I, J. Chromatogr. A, 125, 129 (1976)

[2] Dorsey JG, Dill KA, Chemical Reviews, 89, 331 (1989)

[3] Gritti F, Guiochon G, J. Chromatogr. A, 1097, 98 (2005)

[4] Snyder LR, Principles of adsorption chromatography, Marcel Dekker, New York (1968)

[5] Poppe H, J. Chromatogr. A, 656, 19 (1993)

[6] Guiochon G, Golshan-Shirazi S, Katti A, Fundamenta1s of preparative and nonlinear chromatography, Academic Press, New York (1994)

[7] Nicoud RM, Seidel-Morgenstern A, Isolation Purif., 2, 165 (1996)

[8] Huber JFK, Gerritse RG, J. Chromatogr. A, 58, 137 (1971)

[9] De Jong AWJ, Kraak JC, Poppe H, Nooitgedacht F, J. Chromatogr. A, 193, 181 (1980)

[10] Jacobson JM, Frenz J, Horvath C, Ind. Eng. Chem. Res., 26, 43 (1987)

[11] Jacobson JM, Frenz J, J. Chromatogr. A, 499, 5 (1990)

[12] Golshan-Shirazi S, Godbane S, Guiochon G, Anal. Chem., 60, 2630 (1988)

[13] Liseca O, Hugob P, Seidel-Morgenstern A, J. Chromatogr. A, 908, 19 (2001)

[14] Seidel A, Tscheutschler E, Radeke KH, Gelbin D, Chem. Eng. Sci., 40, 215 (1985)

[15] Ching CB, Chu KH, Ruthven DM, AIChE J., 36, 275 (1990)

[16] Blumel C, Hugo P, Seidel-Morgenstern A, J. Chromatogr. A, 865, 51 (1999)

[17] Chan K, Jensen NS, Silber PM, O’Brien PJ, Chemico-Biological Interactions, 165, 165 (2007)

[18] Lide DR, CRC handbook of chemistry and physics, 75th ed., Boca Raton, Florida (1994)

[19] Cavazzini A, Bardin G, Kaczmarski K, Szabelski P, Al-Bokari M, Guiochon G, J. Chromatogr. A, 957, 111 (2002)