화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Polymer(Korea), Vol.33, No.1, 84-90, January, 2009
Export Citation
시스틴으로 화학흡착된 금 코팅 니티놀 표면에 양쪽성 이온 폴리에틸렌글리콜의 그래프트 및 특성 평가
Grafting and Characterization of Zwitter Ionic Poly(ethylene glycol) on Gold-Coated Nitinol Surface Chemisorbed with L-Cysteine
신홍섭1, 2, 박귀덕1, 김재진1, 김지흥2, †, 한동근1, †
  • 1한국과학기술연구원 바이오소재연구센터
  • 2성균관대학교 화공과
Hong Sub Shin1, 2, Kwideok Park1, Jae-Jin Kim1, Ji Heung Kim2, †, and Dong Keun Han1, †
  • 1Biomaterials Research Center, Korea Institute of Science and Technology, P.O. Box 131, Cheongryang, Seoul 130-650, Korea
  • 2Department of Chemical Engineering, Sungkyunkwan University, 300 Cheoncheon-dong, Jangan-gu, Suwon, Gyeonggi-do 440-746, Korea
E-mail:,
초록
니티놀(Nitinol) 합금(TiNi)은 혈관 스텐트로서 널리 사용되고 있다. 본 연구에서는 니티놀 합금의 혈액적 합성을 개선시키기 위해서 화학적인 표면개질을 행하였다. 먼저 니티놀의 표면을 금으로 코팅한 다음 시스틴(Lcysteine, C/N)을 화학흡착한 후 신규 합성한 양쪽성 이온 폴리에틸렌글리콜(PEG)(PEG-N+-SO3-)을 그래프트시켜서 TiNi-C/N-PEG-N-S를 제조하였다. 양쪽성 이온 PEG가 그래프트된 니티놀의 표면은 ATR-FTIR, ESCA 및 SEM을 통해서 확인하였고 친수성 표면은 물 접촉각의 감소를 통해서 입증하였다. 또한, 단백질 흡착 및 혈소판 점착과 혈액응고시간 측정과 같은 혈액적합성 평가 결과로부터 미처리 니티놀 합금에 비해서 표면개질된 니티놀 합금이 상대적으로 훨씬 우수한 혈액적합성을 나타내었다. 이는 그래프트된 친수성 PEG와 항응혈성 양쪽성 이온의 상승효과에 의해서 혈액적합성을 대폭 개선시킨 것으로 사료된다.
Nitinol alloy (TiNi) has been widely used in vascular stents. To improve the blood compatibility of Nitinol alloy, its surface was chemically modified in this study. Nitinol was first coated with gold, then chemisorbed with L-cysteine (C/N), and followed by grafting of zwitter ionic poly(ethylene glycol) (PEG) (PEG-N+-SO3-) to produce TiNi-C/N-PEG-N-S. The zwitter ionic PEG grafted on the Nitinol surface was identified by ATR-FTIR, ESCA and SEM. The hydrophilized surface was proven by the decrease of water contact angle. In addition, from the blood compatibility tests such as protein adsorption, platelet adhesion, and blood coagulation time, the surface-modified TiNi alloy exhibited a better blood compatibility as compared to the untreated Nitinol control. These results indicated a feasibility of synergistic effect of hydrophilic PEG and antithrombotic zwitter ion.
Keywords:vascular stent;nitinol;chemisorption;zwitter ionic PEG;blood compatibility.
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