Extraction equilibria of penicillin G in four different types of organic solvent systems

Sang Cheol Lee

Journal of Industrial and Engineering Chemistry, Vol.15, No.3, 403-409, May, 2009

DOI10.1016/j.jiec.2008.12.009 Export Citation

Extraction equilibria of penicillin G in four different types of organic solvent systems

Sang Cheol Lee^†

Department of Chemical Engineering, Kunsan National University, Miryong Dong, Kunsan, Chonbuk 573-701, South Korea

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Equilibrium experiments for physical and reactive extraction of penicillin G were carried out with varying pH, overall penicillin concentration and overall amine concentration in liquid.liquid extraction systems with four different types of organic solvents, i.e. amphiprotic solvent, hydrogen-bond donor solvent, hydrogen-bond acceptor solvent, and nonpolar organic solvent. Also, physical and reactive extraction equilibrium models were suggested to find the appropriate equilibrium model for each organic solvent type. By comparison between the experimental data and the calculated results from the extraction equilibrium models, the most probable physical and reactive extraction equilibrium models were determined. The physical extraction equilibriummodels for all types of the organic solvents except for nonpolar organic solvent reflected solute.solvent interaction, while the reactive extraction equilibrium models were dependent on the organic solvent type.

Keywords:Penicillin G;Physical extraction;Reactive extraction;Equilibrium model;Four different solvent types

[References]

Lee SC, Chem. Eng. J., 79(1), 61 (2000)
Lee SC, Ahn BS, Kim JG, Biotechnol. Prog., 18(1), 108 (2002)
Lee SC, J. Ind. Eng. Chem., 14(2), 207 (2008)
Lee SC, Biotechnol. Prog., 22(3), 731 (2006)
Pai RA, Doherty MF, Malone MF, AIChE J., 48(3), 514 (2002)
Smith E, Hossain M, Asia-Pacific J. Chem. Eng., 2, 455 (2007)
Yang CF, Cussler EL, Biotechnol. Bioeng., 69(1), 66 (2000)
Reschke M, Schugerl K, Chem. Eng. J., 28, B1 (1984)
Reschke M, Schugerl K, Chem. Eng. J., 28, B11 (1984)
Reschke M, Schugerl K, Chem. Eng. J., 29, B25 (1984)
Bernazzani L, Carosi MR, Ceccanti N, Conti G, Gianni P, Mollica V, Tine MR, Lepori L, Matteoli E, Phys. Chem. Chem. Phys., 2, 4829 (2000)
Pagliara A, Caron G, Lisa G, Fan W, Gaillard P, Carrupt P, Testa B, Abraham MH, J. Chem. Soc., Perkin Trans., 2, 2639 (1997)
Tayar NE, Tsai R, Testa B, Carrupt P, Leo A, J. Pharm. Sci., 80, 590 (1991)
Davies M, Hallam HE, J. Chem. Ed., 33, 322 (1956)
Okada S, Nakahara H, Yomota C, Chem. Pharm. Bull., 33, 4916 (1985)
Dean JA, Lange’s Handbook of Chemistry, 14th edn, McGraw-Hill, New York (1992)
Lee KH, Lee WK, Sep. Sci. Technol., 29(5), 601 (1994)
Likidis Z, Schugerl K, Biotechnol. Bioeng., 30, 1032 (1987)
Muller B, Schlichting E, Bischoff L, Schugerl K, Appl. Microbiol. Biotechnol., 26, 206 (1987)
Lee C, Yeh H, Yang W, Kan C, Biotechnol. Bioeng., 42, 527 (1993)
Miesiac L, Szymanowski J, J. Radioanal. Nucl. Chem., 228, 77 (1998)

[Referenced By]

[Related Articles]

[1] Lee SC, Chem. Eng. J., 79(1), 61 (2000)

[2] Lee SC, Ahn BS, Kim JG, Biotechnol. Prog., 18(1), 108 (2002)

[3] Lee SC, J. Ind. Eng. Chem., 14(2), 207 (2008)

[4] Lee SC, Biotechnol. Prog., 22(3), 731 (2006)

[5] Pai RA, Doherty MF, Malone MF, AIChE J., 48(3), 514 (2002)

[6] Smith E, Hossain M, Asia-Pacific J. Chem. Eng., 2, 455 (2007)

[7] Yang CF, Cussler EL, Biotechnol. Bioeng., 69(1), 66 (2000)

[8] Reschke M, Schugerl K, Chem. Eng. J., 28, B1 (1984)

[9] Reschke M, Schugerl K, Chem. Eng. J., 28, B11 (1984)

[10] Reschke M, Schugerl K, Chem. Eng. J., 29, B25 (1984)

[11] Bernazzani L, Carosi MR, Ceccanti N, Conti G, Gianni P, Mollica V, Tine MR, Lepori L, Matteoli E, Phys. Chem. Chem. Phys., 2, 4829 (2000)

[12] Pagliara A, Caron G, Lisa G, Fan W, Gaillard P, Carrupt P, Testa B, Abraham MH, J. Chem. Soc., Perkin Trans., 2, 2639 (1997)

[13] Tayar NE, Tsai R, Testa B, Carrupt P, Leo A, J. Pharm. Sci., 80, 590 (1991)

[14] Davies M, Hallam HE, J. Chem. Ed., 33, 322 (1956)

[15] Okada S, Nakahara H, Yomota C, Chem. Pharm. Bull., 33, 4916 (1985)

[16] Dean JA, Lange’s Handbook of Chemistry, 14th edn, McGraw-Hill, New York (1992)

[17] Lee KH, Lee WK, Sep. Sci. Technol., 29(5), 601 (1994)

[18] Likidis Z, Schugerl K, Biotechnol. Bioeng., 30, 1032 (1987)

[19] Muller B, Schlichting E, Bischoff L, Schugerl K, Appl. Microbiol. Biotechnol., 26, 206 (1987)

[20] Lee C, Yeh H, Yang W, Kan C, Biotechnol. Bioeng., 42, 527 (1993)

[21] Miesiac L, Szymanowski J, J. Radioanal. Nucl. Chem., 228, 77 (1998)