Compatibility of Diazepam with Polypropylene Multilayer Infusion Container

Dong Il Noh; Kyu Nam Park; Heung Jae Chun; Chong Won Park; Ju Woong Jang; Yun Gyong Ahn

Macromolecular Research, Vol.17, No.7, 516-521, July, 2009

Export Citation

Compatibility of Diazepam with Polypropylene Multilayer Infusion Container

Dong Il Noh¹, Kyu Nam Park^{2, 3}, Heung Jae Chun^{1, 2, †}, Chong Won Park⁴, Ju Woong Jang⁵, and Yun Gyong Ahn⁶

¹Department of Biomedical Science, Medical College of Catholic University, Seoul 137-701, Korea
²Institute of Cell and Tissue Engineering, Medical College of Catholic University, Seoul 137-701, Korea
³Department of Emergency Medicine, Medical College of Catholic University, Seoul 137-701, Korea
⁴Department of Internal Medicine, Medical College of Catholic University, Seoul 137-701, Korea
⁵Research Institute of Biomedical Engineering, Korea Bone Bank Co. Ltd., Seoul 153-782, Korea
⁶Hazardous Substance Research Team, Korea Basic Science Institute, Seoul 136-701, Korea

E-mail:

Techflex®, a polypropylene-lined, multilayer infusion bag, was studied for its compatibility with diazepam, in comparison to the conventional infusion bag, Safeflex®, which is comprised of poly(vinyl chloride) (PVC). Diazepam was diluted in 0.9% sodium chloride isotonic solution and stored in the infusion bags for 24 h. To evaluate the sorption of diazepam into the infusion bags during storage, the concentration of the drug remaining in the bag was measured using gas chromatography-mass spectroscopy. The PVC bags exhibited a marked sorption of diazepam, with a drug loss reaching up to 90% of the initial concentration after 24 h of contact, whereas Techflex® inhibited the drug sorption, showing approximately 10%, under the same conditions. The differences in the sorption behaviors of the bags are discussed in terms of solubility parameters and crystallinities of the polymers.

Keywords:polypropylene;poly(vinyl chloride);diazepam;infusion;container;bag;multilayer;compatibility;crystallinity;solubility.

[References]

Kambia NK, Dine T, Dupin-Spriet T, Gressier B, Luyckx M, Goudaliez F, Brunet C, J. Pharm. Biomed. Anal., 37, 259 (2005)
Bagel-Boithias S, Sautou-Miranda V, Bourdeaux D, Tramier V, Boyer A, Chopineau J, Am. J. Health. Syst. Pharm., 62, 182 (2005)
Bourdeaux D, Sautou-Miranda V, Bagel-Boithias S, Boyer A, Chopineau J, J. Pharm. Biomed. Anal., 35, 57 (2004)
Allwood MC, Martin H, Int. J. Pharm., 127, 65 (1996)
Gotardo MA, Monteiro M, J. Pharm. Biomed. Anal., 38, 709 (2005)
Haishima Y, Seshimo F, Higuchi T, Yamazaki H, Hasegawa C, Izumi S, Makino T, Nakahashi K, Int. J. Pharm., 298, 126 (2005)
Saido K, Taguchi H, Yada S, Ishihara Y, Kuroki T, Ryu IJ, Chung SY, Macromol. Res., 11(3), 178 (2003)
Beitz C, Bertsch T, Hannak D, Schrammel W, Einberger C, Wehling M, Int. J. Pharm., 185, 113 (1999)
Tchiakpe L, Airaudo CB, Abdelmalik OM, Gayte-Sorbier A, Verdier M, Guerri J, J. Biomater. Sci. Polym. Ed., 7, 199 (1995)
Dyrstad K, Veggeland J, Thomassen C, Int. J. Pharm., 188, 105 (1999)
Quental AC, Felisberti MI, Eur. Polym. J., 41, 894 (2005)
Patterson KG, Padgett SJ, Peppas NA, Colloid Polym. Sci., 260, 851 (1982)
Martens HJ, De Goede PN, Van Loenen AC, Am. J. Hosp. Pharm., 47, 369 (1990)
Fred W, Billmeyer JR, Textbook of polymer science, 3rd ed., John Wiley & Sons, New York (1984)
Min BS, Ko SW, Macromol. Res., 15(3), 225 (2007)
Verheyen S, Augustijns P, Kinget R, Mooter GV, Int. J. Pharm., 228, 199 (2001)
Takehisa H, Naoko E, Masahiko S, Katsuhide T, Moriyuki O, Keizoh S, Kenji K, Shin'ichiro N, Toshio O, Int. J. Pharm., 297, 30 (2005)

[Referenced By]

[1] Kambia NK, Dine T, Dupin-Spriet T, Gressier B, Luyckx M, Goudaliez F, Brunet C, J. Pharm. Biomed. Anal., 37, 259 (2005)

[2] Bagel-Boithias S, Sautou-Miranda V, Bourdeaux D, Tramier V, Boyer A, Chopineau J, Am. J. Health. Syst. Pharm., 62, 182 (2005)

[3] Bourdeaux D, Sautou-Miranda V, Bagel-Boithias S, Boyer A, Chopineau J, J. Pharm. Biomed. Anal., 35, 57 (2004)

[4] Allwood MC, Martin H, Int. J. Pharm., 127, 65 (1996)

[5] Gotardo MA, Monteiro M, J. Pharm. Biomed. Anal., 38, 709 (2005)

[6] Haishima Y, Seshimo F, Higuchi T, Yamazaki H, Hasegawa C, Izumi S, Makino T, Nakahashi K, Int. J. Pharm., 298, 126 (2005)

[7] Saido K, Taguchi H, Yada S, Ishihara Y, Kuroki T, Ryu IJ, Chung SY, Macromol. Res., 11(3), 178 (2003)

[8] Beitz C, Bertsch T, Hannak D, Schrammel W, Einberger C, Wehling M, Int. J. Pharm., 185, 113 (1999)

[9] Tchiakpe L, Airaudo CB, Abdelmalik OM, Gayte-Sorbier A, Verdier M, Guerri J, J. Biomater. Sci. Polym. Ed., 7, 199 (1995)

[10] Dyrstad K, Veggeland J, Thomassen C, Int. J. Pharm., 188, 105 (1999)

[11] Quental AC, Felisberti MI, Eur. Polym. J., 41, 894 (2005)

[12] Patterson KG, Padgett SJ, Peppas NA, Colloid Polym. Sci., 260, 851 (1982)

[13] Martens HJ, De Goede PN, Van Loenen AC, Am. J. Hosp. Pharm., 47, 369 (1990)

[14] Fred W, Billmeyer JR, Textbook of polymer science, 3rd ed., John Wiley & Sons, New York (1984)

[15] Min BS, Ko SW, Macromol. Res., 15(3), 225 (2007)

[16] Verheyen S, Augustijns P, Kinget R, Mooter GV, Int. J. Pharm., 228, 199 (2001)

[17] Takehisa H, Naoko E, Masahiko S, Katsuhide T, Moriyuki O, Keizoh S, Kenji K, Shin'ichiro N, Toshio O, Int. J. Pharm., 297, 30 (2005)