Preparation and Characterization of Nanofibrous Membranes of Poly(D,L-lactic acid)/Chitin Blend for Guided Tissue Regenerative Barrier

Hong Sung Kim; Jong Tae Kim; Young Jin Jung; Dae Youn Hwang; Hong Joo Son; Jae Beom Lee; Su Chak Ryu; Sang Hun Shin

Macromolecular Research, Vol.17, No.9, 682-687, September, 2009

Hong Sung Kim^†, Jong Tae Kim, Young Jin Jung, Dae Youn Hwang, Hong Joo Son, Jae Beom Lee¹, Su Chak Ryu¹, and Sang Hun Shin²

College of Natural Resources & Life Science, Pusan National University, Miryang 627-706, Korea
¹College of Nano Science and Technology, Pusan National University, Miryang 627-706, Korea
²School of Dentistry, Pusan National University, Busan 602-739, Korea

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Nanofibrous membranes of poly(D,L-lactic acid)/chitin blend were prepared by electrospinning for a barrier of guided tissue regeneration. A miscible solution was obtained by the blending chitin-salt complex into 1-methyl-2-pyrrolidone solution of poly(D,L-lactic acid). The properties of the blend were examined for nanofibrous fabrication. The viscosity of the blend solution was increased significantly due to chain entanglement despite the low ratio of chitin to poly(D,L-lactic acid). An interaction between two polymeric compositions was confirmed by Fourier transform infrared spectroscopy. X-ray diffraction detected an appreciably ordered microstructure in the nanofiber of the blend. A membrane of thinner nanofibers was fabricated by electrospinning the chitin blend. The permeability of the membranes was examined using bioactive model compounds.

Keywords:poly(D,L-lactic acid);chitin;blend;nanofiber;membrane;GTR barrier.

[References]

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Fujihara K, Kotaki M, Biomaterials, 26, 4139 (2005)
Maeda H, Kasuga T, Hench LL, Biomaterials, 27, 1216 (2006)
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Lee JS, Kim JK, Park SR, Chang YH, Macromol. Res., 15(3), 205 (2007)
Kim K, Yu M, Zong X, Chiu J, Fang D, Seo YS, Hsiao BS, Chu B, Hadjiargyrou M, Biomaterials, 24, 4977 (2003)
Christgau M, Bader N, Schmalz G, Hiller KA, Wenzel A, Clin. Oral Invest., 1, 109 (1997)
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Park H, Lee KY, Lee SJ, Park KE, Park WH, Macromol. Res., 15(3), 238 (2007)
Zong X, Kim K, Fang D, Ran S, Hsiao BS, Chu B, Polymer, 43, 4406 (2002)
Kim K, Luu YK, Chang C, Fang D, Hsiao BS, Chu B, Hadjiargyrou M, J. Control. Release, 98, 47 (2004)
Badami AS, Kreke MR, Thompson MS, Riffle JS, Goldstein AS, Biomaterials, 27, 596 (2006)
Kim JY, Ha CS, Jo NJ, Polym. Int., 51, 1123 (2002)
Peesan M, Supaphol P, Rujiravanit R, Carbohyd. Polym., 60, 343 (2005)
Peesan M, Rujiravanit R, Supaphol P, J. Biomater. Sci. Polym. Edn., 17, 547 (2006)
Li LH, Ding S, Zhou CR, J. Appl. Polym. Sci., 91(1), 274 (2004)
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Duan B, Yuan X, Zhu Y, Zhang Y, Li X, Zhang Y, Yao K, Eur. Polym. J., 42, 2013 (2006)
Kim HS, Kim JT, Ryu SC, Kim JH, Biomaterials Research, 11, 96 (2007)
Kim HS, Kim JT, Jung YJ, Ryu SC, Son HJ, Kim YG, Macromol. Res., 15(1), 65 (2007)
Liu X, Zou Y, Li W, Cao G, Chen W, Polym. Degrad. Stabil., 91, 3259 (2006)
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[Referenced By]

[1] Stavropoulos A, Sculean A, Karring T, Clin Oral Invest, 8, 226 (2004)

[2] Fujihara K, Kotaki M, Biomaterials, 26, 4139 (2005)

[3] Maeda H, Kasuga T, Hench LL, Biomaterials, 27, 1216 (2006)

[4] Carvalho RS, Nelson D, Kelderman H, Wise R, Am. J. Orthod. Dentofacial Orthop., 123, 455 (2003)

[5] Piattelli A, Scarano A, Russo P, Matarasso S, Biomaterials, 17, 791 (1996)

[6] Dupoirieux L, Pourquier D, Picot MC, Neves M, Int. J. Oral Maxillofac. Surg., 30, 58 (2001)

[7] Taguchi Y, Amizuka N, Nakadate M, Ohnishi H, Fujii N, Oda K, Nomura S, Maeda T, Biomaterials, 26, 6158 (2005)

[8] Liao S, Wang W, Uo M, Ohkawa S, Akasaka T, Tamura K, Cui F, Watari F, Biomaterials, 26, 7564 (2005)

[9] Lee JS, Kim SC, Lee HK, Macromol. Res., 16(7), 631 (2008)

[10] Lee JS, Kim JK, Park SR, Chang YH, Macromol. Res., 15(3), 205 (2007)

[11] Kim K, Yu M, Zong X, Chiu J, Fang D, Seo YS, Hsiao BS, Chu B, Hadjiargyrou M, Biomaterials, 24, 4977 (2003)

[12] Christgau M, Bader N, Schmalz G, Hiller KA, Wenzel A, Clin. Oral Invest., 1, 109 (1997)

[13] Kumar MNVR, React. Funct. Polym., 46, 1 (2000)

[14] Rinaudo M, Prog. Polym. Sci., 31, 603 (2006)

[15] Mori T, Okumura M, Matsuura M, Ueno K, Tokura S, Okamoto Y, Minami S, Fujinaga T, Biomaterials, 18, 947 (1997)

[16] Park H, Lee KY, Lee SJ, Park KE, Park WH, Macromol. Res., 15(3), 238 (2007)

[17] Zong X, Kim K, Fang D, Ran S, Hsiao BS, Chu B, Polymer, 43, 4406 (2002)

[18] Kim K, Luu YK, Chang C, Fang D, Hsiao BS, Chu B, Hadjiargyrou M, J. Control. Release, 98, 47 (2004)

[19] Badami AS, Kreke MR, Thompson MS, Riffle JS, Goldstein AS, Biomaterials, 27, 596 (2006)

[20] Kim JY, Ha CS, Jo NJ, Polym. Int., 51, 1123 (2002)

[21] Peesan M, Supaphol P, Rujiravanit R, Carbohyd. Polym., 60, 343 (2005)

[22] Peesan M, Rujiravanit R, Supaphol P, J. Biomater. Sci. Polym. Edn., 17, 547 (2006)

[23] Li LH, Ding S, Zhou CR, J. Appl. Polym. Sci., 91(1), 274 (2004)

[24] Min BM, You Y, Kim JM, Lee SJ, Park WH, Carbohyd. Polym., 57, 285 (2004)

[25] Duan B, Yuan X, Zhu Y, Zhang Y, Li X, Zhang Y, Yao K, Eur. Polym. J., 42, 2013 (2006)

[26] Kim HS, Kim JT, Ryu SC, Kim JH, Biomaterials Research, 11, 96 (2007)

[27] Kim HS, Kim JT, Jung YJ, Ryu SC, Son HJ, Kim YG, Macromol. Res., 15(1), 65 (2007)

[28] Liu X, Zou Y, Li W, Cao G, Chen W, Polym. Degrad. Stabil., 91, 3259 (2006)

[29] Zhang Y, Xue C, Xue Y, Gao R, Zhang X, Carbohyd. Res., 340, 1914 (2005)