The response surface methodology was used to find the optimal condition for electrolytic Pb(II) removal by using, as the experimental design, a central composite rotatable design for two variables (current and flow rate) at five levels. The surfaces generated with the second-order-equation fitted data showed the positive influence of increasing the current variable on the removal efficiency, leading to 93% removal after 30-min electrolysis. However, high current values lowered the current efficiency due to parasitic reactions. On the other hand, the flow rate variable did not substantially affect either the removal or the current efficiency. Electrolysis carried out at the optimised condition (250 L h(-1) and -0.25 A), after 90-min electrolysis, lowered the Pb(II) concentration from 50 ppm to 0.5 ppm, corresponding to 99% removal.