Hydrogels are of great interest in delivering drugs through their polymeric network. Hydrogels of macroporous copolymer 2-hydroxy ethyl methacrylate (HEMA) with acrylic acid (AA) were prepared in the presence of N,N'-methylene-bis-acrylamide as crosslinker and benzoyl peroxide as initiator. T e structure of the copolymer, hydrogel character, and biodegradability have already been discussed in our previous article (Mohapatra et al., Polym Polym Compos 2005, 13, 807) entitled P(HEMA-co-AA) as Novel Biodegradable Macroporous Hydrogel. The current study involves the in vitro and in vivo release of alfuzosin hydrochloride at pH 7.0 and 9.2, taking different concentrations of drug and hydrogel. The percentage of drug entrapment study was done and the stability study was also performed according to I.C.H. guidelines for a period of 6 months giving satisfactory results. (c) 2007 Wiley Periodicals, Inc.